Trauma-induced coagulopathy. A narrative review of goal-directed hemostatic resuscitation
نویسندگان
چکیده
منابع مشابه
Early and individualized goal-directed therapy for trauma-induced coagulopathy
Severe trauma-related bleeding is associated with high mortality. Standard coagulation tests provide limited information on the underlying coagulation disorder. Whole-blood viscoelastic tests such as rotational thromboelastometry or thrombelastography offer a more comprehensive insight into the coagulation process in trauma. The results are available within minutes and they provide information ...
متن کاملHemostatic resuscitation for acute traumatic coagulopathy
Trauma resuscitation paradigms have changed considerably over the last twenty years. Originally, the goal was to normalize a blood pressure as quickly as possible. Large volume crystalloid resuscitation was used to accomplish this. Standard therapy was that any patient with suspected bleeding received a two liter crystalloid bolus as initial therapy. It was often repeated and blood transfusion ...
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The identification and management of coagulopathy is a critical component of caring for the severely injured patient. Notions of the mechanisms of coagulopathy in trauma patients have been supplanted by new insights resulting from close examination of the biochemical and cellular changes associated with acute tissue injury and hemorrhagic shock. Acute intrinsic coagulopathy arising in severely ...
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Trauma-induced coagulopathy (TIC) is a recently described condition which traditionally has been diagnosed by the common coagulation tests (CCTs) such as prothrombin time/international normalized ratio (PT/INR), activated partial thromboplastin time (aPTT), platelet count, and fibrinogen levels. The varying sensitivity and specificity of these CCTs have led trauma coagulation researchers and cl...
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John B. Holcomb, MD, FACS, Don Jenkins, MD, FACS, Peter Rhee, MD, FACS, Jay Johannigman, MD, FS, FACS, Peter Mahoney, FRCA, RAMC, Sumeru Mehta, MD, E. Darrin Cox, MD, FACS, Michael J. Gehrke, MD, Greg J. Beilman, MD, FACS, Martin Schreiber, MD, FACS, Stephen F. Flaherty, MD, FACS, Kurt W. Grathwohl, MD, Phillip C. Spinella, MD, Jeremy G. Perkins, MD, Alec C. Beekley, MD, FACS, Neil R. McMullin,...
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ژورنال
عنوان ژورنال: Emergency Care Journal
سال: 2018
ISSN: 2282-2054,1826-9826
DOI: 10.4081/ecj.2018.7569